| MAP4K1 (HPK1) | STE20 | STE | 8fh4 | A | A | (3p)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | Human | 14688 | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9l | A | | 2-amino-n,n-dimethyl-5-(1h-pyrrolo[2,3-b]pyridin-5-yl)benzamide | Human | 14026 | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9p | A | | 6-amino-2-fluoro-n,n-dimethyl-3-(4'-methylspiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl)benzamide | Human | 14022 | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9t | A | | 6-amino-3-[(1s,3r)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-n,n-dimethylbenzamide | Human | 14024 | |
| MAP4K1 (HPK1) | STE20 | STE | 9h8e | A | | 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(4-morpholin-4-ylphenyl)amino]pyrazine-2-carboxamide | Human | 15776 | |
| MAP4K1 (HPK1) | STE20 | STE | 9czx | A | | 4-[(1r)-1-aminopropyl]-2-{6-[(4s,5s)-5-methyl-6,7-dihydro-5h-pyrrolo[2,1-c][1,2,4]triazol-3-yl]pyridin-2-yl}-6-[(2r)-2-methylpyrrolidin-1-yl]-2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-one | Human | 15777 | |
| MAP4K1 (HPK1) | STE20 | STE | 9nc2 | A | B | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | 15775 | |
| MAP4K1 (HPK1) | STE20 | STE | 9nc2 | A | A | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | 15778 | |
| MAP4K1 (HPK1) | STE20 | STE | 9h8d | A | | 6-(1-methylbenzimidazol-4-yl)-3-[(4-morpholin-4-ylphenyl)amino]pyrazine-2-carboxamide | Human | 15785 | |
| MAP4K1 (HPK1) | STE20 | STE | 9d00 | A | | 4-[(1r)-1-aminopropyl]-6-methoxy-2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one | Human | 15784 | |
| MAP4K1 (HPK1) | STE20 | STE | 8fh4 | A | B | (3p)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | Human | 14690 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | B | A | - | Human | 10805 | |
| MAP4K1 (HPK1) | STE20 | STE | 8fko | A | | (3p)-3-{4-[(2s,5r)-5-amino-2-methylpiperidin-1-yl]-6-chloro-7h-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | Human | 14689 | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfz | B | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11074 | |
| MAP4K1 (HPK1) | STE20 | STE | 8cdw | A | B | ~{n}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine | Human | 14895 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | C | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13474 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | A | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13418 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | A | | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13475 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | B | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13426 | |
| MAP4K1 (HPK1) | STE20 | STE | 6ng0 | B | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11073 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | C | | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13478 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | D | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13479 | |
| MAP4K1 (HPK1) | STE20 | STE | 9czw | A | | 6-(dimethylamino)-4-[(methylamino)methyl]-2-[6-(4-propyl-4h-1,2,4-triazol-3-yl)pyridin-2-yl]-2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-one | Human | 15780 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | B | | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13466 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | B | A | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13467 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | A | A | - | Human | 10802 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | D | | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13468 | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9n | A | B | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | 14023 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | A | A | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13469 | |
| MAP4K1 (HPK1) | STE20 | STE | 7kac | B | | 5-{[4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1(3h)-one | Human | 13230 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | B | A | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | 13413 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqd | B | | phosphoaminophosphonic acid-adenylate ester | Human | 10801 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | B | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13470 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqf | A | | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | 10806 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | B | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13414 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | D | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13415 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | A | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13416 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | D | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13471 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | B | B | - | Human | 10800 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | B | B | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13472 | |
| MAP4K1 (HPK1) | STE20 | STE | 7siu | A | | 6-[(5r)-5-benzamidocyclohex-1-en-1-yl]-3-[(1-methyl-1h-pyrazol-4-yl)amino]pyrazine-2-carboxamide | Human | 14117 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | C | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13417 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | C | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13473 | |
| MAP4K1 (HPK1) | STE20 | STE | 6ng0 | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11071 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | C | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13419 | |
| MAP4K1 (HPK1) | STE20 | STE | 9czt | A | | 4-(aminomethyl)-2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one | Human | 15783 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | C | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13420 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | D | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13421 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqd | A | | phosphoaminophosphonic acid-adenylate ester | Human | 10803 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | B | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13422 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | C | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | 13423 | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | B | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11077 | |
| MAP4K1 (HPK1) | STE20 | STE | 7kac | A | | 5-{[4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1(3h)-one | Human | 13231 | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | A | B | - | Human | 10804 | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11075 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | B | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13476 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | A | B | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | 13424 | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9n | A | A | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | 14025 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | A | B | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13477 | |
| MAP4K1 (HPK1) | STE20 | STE | 8pau | A | | [(5~{r})-2-[[3,5-bis(fluoranyl)-4-[[3-(trifluoromethyl)-1~{h}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]amino]-5-fluoranyl-4,6-dihydro-1,3-oxazin-5-yl]methanol | Human | 15317 | |
| MAP4K1 (HPK1) | STE20 | STE | 8cdw | A | A | ~{n}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine | Human | 14896 | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfz | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11078 | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | B | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11076 | |
| MAP4K1 (HPK1) | STE20 | STE | 9h8f | A | | 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-1-[2,2,2-tris(fluoranyl)ethyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide | Human | 15779 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | B | B | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | 13425 | |
| MAP4K1 (HPK1) | STE20 | STE | 8fjz | A | | (3p)-3-{4-[(3r,5s)-3-amino-5-methylpiperidin-1-yl]-6-chloro-7h-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | Human | 14691 | |
| MAP4K1 (HPK1) | STE20 | STE | 8pas | A | | 4-[2,6-bis(fluoranyl)-4-(3-morpholin-4-ylpropylcarbamoylamino)phenoxy]-~{n}-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-1~{h}-pyrrolo[2,3-b]pyridine-3-carboxamide | Human | 15318 | |
| MAP4K1 (HPK1) | STE20 | STE | 8cij | A | | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{h}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{h}-pyrazolo[1,5-d][1,4]diazepin-7-one | Human | 14897 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | A | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13427 | |
| MAP4K1 (HPK1) | STE20 | STE | 9wd3 | A | | 5-(8-methoxyimidazo[1,2-a]pyridin-3-yl)-7,7-dimethyl-9-morpholin-4-yl-2,12-dihydrobenzo[b][1,9]phenanthrolin-1-one | Human | 15782 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | A | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13480 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | A | A | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | 13428 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | A | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13429 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | B | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13430 | |
| MAP4K1 (HPK1) | STE20 | STE | 31wc | A | | 2-cyclopropyl-8-(3-methoxy-1-methyl-pyrazol-4-yl)-3-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrido[3,4-b]pyrazin-5-amine | Human | 15781 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | A | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13481 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | D | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13431 | |
| MAP4K1 (HPK1) | STE20 | STE | 8par | A | | ~{n}-[3,5-bis(fluoranyl)-4-[[3-[1-(trifluoromethyl)cyclopropyl]-1~{h}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-2,9-dioxa-4-azaspiro[5.5]undec-3-en-3-amine | Human | 15319 | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | D | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | 13432 | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11072 | |
