| IRAK4 | IRAK | TKL | 8v2f | A | A | n-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15333 | |
| IRAK4 | IRAK | TKL | 6mom | B | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11745 | |
| IRAK4 | IRAK | TKL | 5w85 | A | | 6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino}-n-methylpyridine-3-carboxamide | Human | 8560 | |
| IRAK4 | IRAK | TKL | 5uit | A | | 1-{[(2s)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide | Human | 7606 | |
| IRAK4 | IRAK | TKL | 7qg5 | A | A | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | Human | 14211 | |
| IRAK4 | IRAK | TKL | 7qg1 | A | | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | 14212 | |
| IRAK4 | IRAK | TKL | 6vql | B | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12394 | |
| IRAK4 | IRAK | TKL | 5t1t | C | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7564 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10905 | |
| IRAK4 | IRAK | TKL | 6ti8 | C | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12945 | |
| IRAK4 | IRAK | TKL | 6o95 | A | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11104 | |
| IRAK4 | IRAK | TKL | 5kx8 | D | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6961 | |
| IRAK4 | IRAK | TKL | 2nru | A | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1748 | |
| IRAK4 | IRAK | TKL | 6thz | A | | 7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12948 | |
| IRAK4 | IRAK | TKL | 2oic | A | | staurosporine | Human | 1739 | |
| IRAK4 | IRAK | TKL | 8atn | A | A | ~{n}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 14965 | |
| IRAK4 | IRAK | TKL | 4yp8 | C | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1735 | |
| IRAK4 | IRAK | TKL | 6ege | D | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10896 | |
| IRAK4 | IRAK | TKL | 8br6 | A | A | ~{n}-[6-methoxy-2-(2-methylsulfonylethyl)-1,3-dihydroindazol-5-yl]-6-(2-oxidanylpropan-2-yl)pyridine-2-carboxamide | Human | 15191 | |
| IRAK4 | IRAK | TKL | 6o8u | B | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11120 | |
| IRAK4 | IRAK | TKL | 8br7 | A | | 3-nitro-~{n}-[2-[2-oxidanylidene-2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl]indazol-5-yl]benzamide | Human | 15188 | |
| IRAK4 | IRAK | TKL | 4ztn | A | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6007 | |
| IRAK4 | IRAK | TKL | 6o94 | C | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11118 | |
| IRAK4 | IRAK | TKL | 2oic | D | | staurosporine | Human | 1755 | |
| IRAK4 | IRAK | TKL | 6o9d | D | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11114 | |
| IRAK4 | IRAK | TKL | 4y73 | A | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9123 | |
| IRAK4 | IRAK | TKL | 5k7g | D | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8716 | |
| IRAK4 | IRAK | TKL | 5k7g | A | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8722 | |
| IRAK4 | IRAK | TKL | 6o94 | B | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11098 | |
| IRAK4 | IRAK | TKL | 6o8u | C | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11093 | |
| IRAK4 | IRAK | TKL | 6o94 | B | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11117 | |
| IRAK4 | IRAK | TKL | 6vql | D | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12392 | |
| IRAK4 | IRAK | TKL | 6uya | A | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11810 | |
| IRAK4 | IRAK | TKL | 6o8u | B | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11096 | |
| IRAK4 | IRAK | TKL | 5uit | B | | 1-{[(2s)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide | Human | 7597 | |
| IRAK4 | IRAK | TKL | 7c2v | C | A | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 12999 | |
| IRAK4 | IRAK | TKL | 7c2v | A | B | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 13001 | |
| IRAK4 | IRAK | TKL | 7c2v | C | B | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 13003 | |
| IRAK4 | IRAK | TKL | 7qg2 | A | B | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | 14215 | |
| IRAK4 | IRAK | TKL | 8br5 | A | B | ~{n}-[2,3-dimethyl-6-(1~{h}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15189 | |
| IRAK4 | IRAK | TKL | 8br6 | A | B | ~{n}-[6-methoxy-2-(2-methylsulfonylethyl)-1,3-dihydroindazol-5-yl]-6-(2-oxidanylpropan-2-yl)pyridine-2-carboxamide | Human | 15190 | |
| IRAK4 | IRAK | TKL | 8br5 | A | A | ~{n}-[2,3-dimethyl-6-(1~{h}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15187 | |
| IRAK4 | IRAK | TKL | 2nru | B | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1749 | |
| IRAK4 | IRAK | TKL | 6lxy | D | | n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | Human | 13161 | |
| IRAK4 | IRAK | TKL | 4ztn | B | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6005 | |
| IRAK4 | IRAK | TKL | 7c2w | A | A | - | Human | 12996 | |
| IRAK4 | IRAK | TKL | 4ztl | A | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5994 | |
| IRAK4 | IRAK | TKL | 5uis | D | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7602 | |
| IRAK4 | IRAK | TKL | 2nry | C | A | staurosporine | Human | 1779 | |
| IRAK4 | IRAK | TKL | 9pst | A | | n-[(1r,4r)-4-(5-{(6p)-6-[(8r)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)cyclohexyl]acetamide | Human | 15982 | |
| IRAK4 | IRAK | TKL | 8sce | A | A | n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15983 | |
| IRAK4 | IRAK | TKL | 8scv | A | B | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15973 | |
| IRAK4 | IRAK | TKL | 9na2 | A | | (6p)-6-[(8r)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-(methylamino)pyridine-3-carboxamide | Human | 15974 | |
| IRAK4 | IRAK | TKL | 9r9k | A | | ~{n}-[3-aminocarbonyl-1-(oxan-4-yl)pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide | Human | 15975 | |
| IRAK4 | IRAK | TKL | 8scv | B | A | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15976 | |
| IRAK4 | IRAK | TKL | 9psu | A | | n-[(1r,5s,8r)-3-(5-{(6p)-6-[(8s)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)-3-azabicyclo[3.2.1]octan-8-yl]acetamide | Human | 15977 | |
| IRAK4 | IRAK | TKL | 9r9g | A | | n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15978 | |
| IRAK4 | IRAK | TKL | 8scv | B | B | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15979 | |
| IRAK4 | IRAK | TKL | 9na6 | A | | (6p)-4-{[(1s)-1-cyanoethyl]amino}-6-[(8s)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-n-[(2s)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 15980 | |
| IRAK4 | IRAK | TKL | 8scv | A | A | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15981 | |
| IRAK4 | IRAK | TKL | 9pss | A | | (7p,8s)-7-{(5m)-5-[1-(oxan-4-yl)-1h-1,2,3-triazol-4-yl]-4-[(propan-2-yl)amino]pyridin-2-yl}pyrrolo[1,2-b]pyridazine-3-carbonitrile | Human | 15984 | |
| IRAK4 | IRAK | TKL | 9r9j | A | | ~{n}-[2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)indazol-5-yl]-1-(2-methylpyridin-4-yl)pyrazole-3-carboxamide | Human | 15985 | |
| IRAK4 | IRAK | TKL | 8scw | A | | (6m)-6-(5-cyano-1h-pyrazolo[3,4-b]pyridin-1-yl)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15986 | |
| IRAK4 | IRAK | TKL | 8sce | A | B | n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15987 | |
| IRAK4 | IRAK | TKL | 8dks | A | B | (1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | Human | 14315 | |
| IRAK4 | IRAK | TKL | 8dks | A | A | (1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | Human | 14316 | |
| IRAK4 | IRAK | TKL | 6mom | D | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11744 | |
| IRAK4 | IRAK | TKL | 5uis | B | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7601 | |
| IRAK4 | IRAK | TKL | 8atl | B | A | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14961 | |
| IRAK4 | IRAK | TKL | 8wtf | A | A | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 14960 | |
| IRAK4 | IRAK | TKL | 8atn | A | B | ~{n}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 14962 | |
| IRAK4 | IRAK | TKL | 8atl | A | A | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14964 | |
| IRAK4 | IRAK | TKL | 8atl | B | B | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14966 | |
| IRAK4 | IRAK | TKL | 5k7g | B | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8706 | |
| IRAK4 | IRAK | TKL | 5k75 | B | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8713 | |
| IRAK4 | IRAK | TKL | 2nry | A | A | staurosporine | Human | 1753 | |
| IRAK4 | IRAK | TKL | 2nru | A | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1760 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10909 | |
| IRAK4 | IRAK | TKL | 5uir | A | B | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7600 | |
| IRAK4 | IRAK | TKL | 8atb | A | B | ~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15079 | |
| IRAK4 | IRAK | TKL | 4y73 | C | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9124 | |
| IRAK4 | IRAK | TKL | 4u97 | B | | staurosporine | Human | 1742 | |
| IRAK4 | IRAK | TKL | 6f3d | A | | 4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide | Human | 9925 | |
| IRAK4 | IRAK | TKL | 2oic | B | | staurosporine | Human | 1752 | |
| IRAK4 | IRAK | TKL | 5t1s | A | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7568 | |
| IRAK4 | IRAK | TKL | 5k76 | B | B | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8708 | |
| IRAK4 | IRAK | TKL | 6o9d | C | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11115 | |
| IRAK4 | IRAK | TKL | 4yp8 | A | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1740 | |
| IRAK4 | IRAK | TKL | 6o94 | D | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11108 | |
| IRAK4 | IRAK | TKL | 2nru | D | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1762 | |
| IRAK4 | IRAK | TKL | 6ti8 | C | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12946 | |
| IRAK4 | IRAK | TKL | 2nry | C | B | staurosporine | Human | 1750 | |
| IRAK4 | IRAK | TKL | 6uya | D | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11813 | |
| IRAK4 | IRAK | TKL | 6ti8 | B | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12949 | |
| IRAK4 | IRAK | TKL | 6thw | A | | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12950 | |
| IRAK4 | IRAK | TKL | 5uiu | B | B | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7609 | |
| IRAK4 | IRAK | TKL | 7c2v | A | A | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 12997 | |
| IRAK4 | IRAK | TKL | 6o94 | C | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11095 | |
| IRAK4 | IRAK | TKL | 5uiu | B | A | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7607 | |
| IRAK4 | IRAK | TKL | 6o95 | D | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11101 | |
| IRAK4 | IRAK | TKL | 6f3i | B | | (3~{r})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide | Human | 9922 | |
| IRAK4 | IRAK | TKL | 7c2w | B | A | - | Human | 12998 | |
| IRAK4 | IRAK | TKL | 2oid | B | | phosphoaminophosphonic acid-adenylate ester | Human | 1759 | |
| IRAK4 | IRAK | TKL | 2nru | C | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1776 | |
| IRAK4 | IRAK | TKL | 2nry | A | B | staurosporine | Human | 1777 | |
| IRAK4 | IRAK | TKL | 7c2w | D | A | - | Human | 13000 | |
| IRAK4 | IRAK | TKL | 2oic | C | | staurosporine | Human | 1734 | |
| IRAK4 | IRAK | TKL | 2o8y | A | | - | Human | 1744 | |
| IRAK4 | IRAK | TKL | 5kx8 | A | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6958 | |
| IRAK4 | IRAK | TKL | 6n8g | B | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10791 | |
| IRAK4 | IRAK | TKL | 4ztl | D | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5996 | |
| IRAK4 | IRAK | TKL | 5uiq | C | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7616 | |
| IRAK4 | IRAK | TKL | 4rmz | B | B | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6350 | |
| IRAK4 | IRAK | TKL | 2oib | A | B | - | Human | 1766 | |
| IRAK4 | IRAK | TKL | 4ztn | B | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6001 | |
| IRAK4 | IRAK | TKL | 6o95 | B | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11106 | |
| IRAK4 | IRAK | TKL | 2oib | C | B | - | Human | 1741 | |
| IRAK4 | IRAK | TKL | 6mom | B | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11743 | |
| IRAK4 | IRAK | TKL | 5uiu | A | B | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7615 | |
| IRAK4 | IRAK | TKL | 7qg3 | A | | 6-[(2~{s})-2-fluoranylpropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | 14213 | |
| IRAK4 | IRAK | TKL | 6thz | B | | 7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12951 | |
| IRAK4 | IRAK | TKL | 6ti8 | B | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12952 | |
| IRAK4 | IRAK | TKL | 8tvm | A | A | n-{1-[(1r,2r)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15337 | |
| IRAK4 | IRAK | TKL | 8tx0 | A | | ~{n}-(1-cyclopropyl-2-oxidanylidene-pyridin-3-yl)-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-7-propan-2-yloxy-imidazo[1,2-a]pyrimidine-6-carboxamide | Human | 15340 | |
| IRAK4 | IRAK | TKL | 5t1s | C | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7561 | |
| IRAK4 | IRAK | TKL | 2oid | C | | phosphoaminophosphonic acid-adenylate ester | Human | 1775 | |
| IRAK4 | IRAK | TKL | 5k76 | A | A | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8712 | |
| IRAK4 | IRAK | TKL | 4y73 | D | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9127 | |
| IRAK4 | IRAK | TKL | 5kx8 | C | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6960 | |
| IRAK4 | IRAK | TKL | 4ztn | C | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 5991 | |
| IRAK4 | IRAK | TKL | 5k75 | A | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8725 | |
| IRAK4 | IRAK | TKL | 6mom | D | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11741 | |
| IRAK4 | IRAK | TKL | 4u9a | B | | staurosporine | Human | 1792 | |
| IRAK4 | IRAK | TKL | 8v2l | A | B | n-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15335 | |
| IRAK4 | IRAK | TKL | 6o8u | D | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11119 | |
| IRAK4 | IRAK | TKL | 5kx8 | B | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6959 | |
| IRAK4 | IRAK | TKL | 8tvm | A | B | n-{1-[(1r,2r)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15336 | |
| IRAK4 | IRAK | TKL | 5kx7 | B | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide | Human | 6957 | |
| IRAK4 | IRAK | TKL | 5k75 | A | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8727 | |
| IRAK4 | IRAK | TKL | 6o9d | A | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11099 | |
| IRAK4 | IRAK | TKL | 6o9d | A | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11109 | |
| IRAK4 | IRAK | TKL | 6o8u | A | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11113 | |
| IRAK4 | IRAK | TKL | 4u9a | A | | staurosporine | Human | 1751 | |
| IRAK4 | IRAK | TKL | 6ega | B | B | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10910 | |
| IRAK4 | IRAK | TKL | 6o9d | C | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11112 | |
| IRAK4 | IRAK | TKL | 8atl | A | B | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14959 | |
| IRAK4 | IRAK | TKL | 6vql | C | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12393 | |
| IRAK4 | IRAK | TKL | 2nru | B | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1773 | |
| IRAK4 | IRAK | TKL | 5t1t | B | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7562 | |
| IRAK4 | IRAK | TKL | 6mom | C | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11738 | |
| IRAK4 | IRAK | TKL | 2nry | D | B | staurosporine | Human | 1746 | |
| IRAK4 | IRAK | TKL | 5uiq | A | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7596 | |
| IRAK4 | IRAK | TKL | 5uis | C | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7613 | |
| IRAK4 | IRAK | TKL | 6ti8 | A | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12947 | |
| IRAK4 | IRAK | TKL | 6rfi | A | A | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11788 | |
| IRAK4 | IRAK | TKL | 2nru | D | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1787 | |
| IRAK4 | IRAK | TKL | 6n8g | A | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10796 | |
| IRAK4 | IRAK | TKL | 5k75 | C | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8710 | |
| IRAK4 | IRAK | TKL | 5uiq | B | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7619 | |
| IRAK4 | IRAK | TKL | 4ztm | C | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 6006 | |
| IRAK4 | IRAK | TKL | 6o8u | A | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11121 | |
| IRAK4 | IRAK | TKL | 5t1t | D | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7565 | |
| IRAK4 | IRAK | TKL | 6rfi | B | B | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11791 | |
| IRAK4 | IRAK | TKL | 4y73 | A | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9129 | |
| IRAK4 | IRAK | TKL | 6f3g | A | | ~{n}4,~{n}4-dimethyl-~{n}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | Human | 9921 | |
| IRAK4 | IRAK | TKL | 4xs2 | D | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1738 | |
| IRAK4 | IRAK | TKL | 4xs2 | B | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1778 | |
| IRAK4 | IRAK | TKL | 5uis | C | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7611 | |
| IRAK4 | IRAK | TKL | 4yo6 | B | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1747 | |
| IRAK4 | IRAK | TKL | 4ztn | D | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 5995 | |
| IRAK4 | IRAK | TKL | 2oib | D | B | - | Human | 1783 | |
| IRAK4 | IRAK | TKL | 4yp8 | D | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1745 | |
| IRAK4 | IRAK | TKL | 6ega | A | B | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10907 | |
| IRAK4 | IRAK | TKL | 2oib | B | A | - | Human | 1785 | |
| IRAK4 | IRAK | TKL | 4u97 | A | | staurosporine | Human | 1754 | |
| IRAK4 | IRAK | TKL | 5uiu | A | A | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7603 | |
| IRAK4 | IRAK | TKL | 6ti8 | D | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12942 | |
| IRAK4 | IRAK | TKL | 4yo6 | A | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1763 | |
| IRAK4 | IRAK | TKL | 6f3d | B | | 4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide | Human | 9924 | |
| IRAK4 | IRAK | TKL | 4ztl | B | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6009 | |
| IRAK4 | IRAK | TKL | 8v2f | A | B | n-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15330 | |
| IRAK4 | IRAK | TKL | 7qg2 | A | A | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | 14210 | |
| IRAK4 | IRAK | TKL | 4y73 | C | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9130 | |
| IRAK4 | IRAK | TKL | 6mom | C | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11739 | |
| IRAK4 | IRAK | TKL | 8v2l | A | A | n-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15331 | |
| IRAK4 | IRAK | TKL | 6tia | B | | 4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12943 | |
| IRAK4 | IRAK | TKL | 6thx | A | | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | Human | 12944 | |
| IRAK4 | IRAK | TKL | 5k75 | D | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8714 | |
| IRAK4 | IRAK | TKL | 8ucc | A | | (4s)-2-[(1r,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-n-[(8s)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide | Human | 15332 | |
| IRAK4 | IRAK | TKL | 5uiq | C | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7608 | |
| IRAK4 | IRAK | TKL | 5uiq | B | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7617 | |
| IRAK4 | IRAK | TKL | 6o95 | C | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11110 | |
| IRAK4 | IRAK | TKL | 6o8u | D | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11103 | |
| IRAK4 | IRAK | TKL | 6egd | D | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10894 | |
| IRAK4 | IRAK | TKL | 6o9d | B | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11107 | |
| IRAK4 | IRAK | TKL | 8v1o | A | | n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15334 | |
| IRAK4 | IRAK | TKL | 6o95 | A | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11102 | |
| IRAK4 | IRAK | TKL | 5k72 | B | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8711 | |
| IRAK4 | IRAK | TKL | 4rmz | B | A | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6351 | |
| IRAK4 | IRAK | TKL | 2oib | D | A | - | Human | 1736 | |
| IRAK4 | IRAK | TKL | 5uiq | A | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7612 | |
| IRAK4 | IRAK | TKL | 4ztn | D | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6002 | |
| IRAK4 | IRAK | TKL | 4xs2 | C | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1791 | |
| IRAK4 | IRAK | TKL | 7qg5 | A | B | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | Human | 14214 | |
| IRAK4 | IRAK | TKL | 4rmz | A | A | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6349 | |
| IRAK4 | IRAK | TKL | 5t1t | A | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7567 | |
| IRAK4 | IRAK | TKL | 6thx | B | | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | Human | 12953 | |
| IRAK4 | IRAK | TKL | 5uiq | D | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7620 | |
| IRAK4 | IRAK | TKL | 5uir | B | A | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7595 | |
| IRAK4 | IRAK | TKL | 5uis | B | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7618 | |
| IRAK4 | IRAK | TKL | 5t1s | D | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7563 | |
| IRAK4 | IRAK | TKL | 2oid | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1764 | |
| IRAK4 | IRAK | TKL | 6n8g | D | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10789 | |
| IRAK4 | IRAK | TKL | 6mom | A | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11742 | |
| IRAK4 | IRAK | TKL | 6f3e | B | | 2-[(3~{r})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide | Human | 9926 | |
| IRAK4 | IRAK | TKL | 6o94 | A | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11091 | |
| IRAK4 | IRAK | TKL | 4yp8 | B | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1786 | |
| IRAK4 | IRAK | TKL | 6ege | A | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10897 | |
| IRAK4 | IRAK | TKL | 4rmz | A | B | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6352 | |
| IRAK4 | IRAK | TKL | 6egd | D | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10890 | |
| IRAK4 | IRAK | TKL | 8ucb | A | | 6-(difluoromethyl)-n-[(4r)-7-ethoxy-2-{[(3r)-oxolan-3-yl]methyl}imidazo[1,2-a]pyridin-6-yl]pyridine-2-carboxamide | Human | 15338 | |
| IRAK4 | IRAK | TKL | 5uis | A | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7604 | |
| IRAK4 | IRAK | TKL | 5k72 | D | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8721 | |
| IRAK4 | IRAK | TKL | 8tvn | A | A | n-{1-[(1r,2s)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15339 | |
| IRAK4 | IRAK | TKL | 4yo6 | A | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1793 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10906 | |
| IRAK4 | IRAK | TKL | 6vql | A | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12395 | |
| IRAK4 | IRAK | TKL | 6uya | A | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11811 | |
| IRAK4 | IRAK | TKL | 6lxy | E | | n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | Human | 13162 | |
| IRAK4 | IRAK | TKL | 6o9d | B | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11094 | |
| IRAK4 | IRAK | TKL | 6egf | B | | phosphoaminophosphonic acid-adenylate ester | Human | 10893 | |
| IRAK4 | IRAK | TKL | 5w85 | B | | 6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino}-n-methylpyridine-3-carboxamide | Human | 8558 | |
| IRAK4 | IRAK | TKL | 6uya | C | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11814 | |
| IRAK4 | IRAK | TKL | 6o94 | D | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11111 | |
| IRAK4 | IRAK | TKL | 6rfj | B | | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | 11789 | |
| IRAK4 | IRAK | TKL | 5uiq | D | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7610 | |
| IRAK4 | IRAK | TKL | 2o8y | B | | - | Human | 1732 | |
| IRAK4 | IRAK | TKL | 6f3i | A | | (3~{r})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide | Human | 9928 | |
| IRAK4 | IRAK | TKL | 6o9d | D | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11100 | |
| IRAK4 | IRAK | TKL | 2nry | B | B | staurosporine | Human | 1772 | |
| IRAK4 | IRAK | TKL | 6n8g | C | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10794 | |
| IRAK4 | IRAK | TKL | 6mom | A | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11740 | |
| IRAK4 | IRAK | TKL | 5w84 | A | | 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]pyridine-3-carboxamide | Human | 8559 | |
| IRAK4 | IRAK | TKL | 2oib | A | A | - | Human | 1756 | |
| IRAK4 | IRAK | TKL | 6o95 | D | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11105 | |
| IRAK4 | IRAK | TKL | 6uya | C | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11808 | |
| IRAK4 | IRAK | TKL | 4ztl | C | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5998 | |
| IRAK4 | IRAK | TKL | 6n8g | D | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10792 | |
| IRAK4 | IRAK | TKL | 4y73 | B | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9128 | |
| IRAK4 | IRAK | TKL | 8atb | A | A | ~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15080 | |
| IRAK4 | IRAK | TKL | 6egd | A | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10892 | |
| IRAK4 | IRAK | TKL | 6n8g | B | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10790 | |
| IRAK4 | IRAK | TKL | 6rfi | B | A | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11790 | |
| IRAK4 | IRAK | TKL | 2oib | C | A | - | Human | 1781 | |
| IRAK4 | IRAK | TKL | 6lxy | B | | n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | Human | 13163 | |
| IRAK4 | IRAK | TKL | 4ztm | B | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 5992 | |
| IRAK4 | IRAK | TKL | 6n8g | C | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10793 | |
| IRAK4 | IRAK | TKL | 4y73 | B | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9125 | |
| IRAK4 | IRAK | TKL | 8wtf | A | B | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 14963 | |
| IRAK4 | IRAK | TKL | 5uir | B | B | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7605 | |
| IRAK4 | IRAK | TKL | 6o95 | B | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11090 | |
| IRAK4 | IRAK | TKL | 4ztl | A | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6003 | |
| IRAK4 | IRAK | TKL | 4xs2 | A | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1765 | |
| IRAK4 | IRAK | TKL | 6uya | B | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11812 | |
| IRAK4 | IRAK | TKL | 6o94 | A | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11092 | |
| IRAK4 | IRAK | TKL | 5kx7 | A | | - | Human | 6956 | |
| IRAK4 | IRAK | TKL | 4y73 | D | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9126 | |
| IRAK4 | IRAK | TKL | 5t1s | B | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7566 | |
| IRAK4 | IRAK | TKL | 4ztm | A | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 5997 | |
| IRAK4 | IRAK | TKL | 4yo6 | B | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1769 | |
| IRAK4 | IRAK | TKL | 4ztn | A | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 5993 | |
| IRAK4 | IRAK | TKL | 6uya | B | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11807 | |
| IRAK4 | IRAK | TKL | 5uir | A | A | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7599 | |
| IRAK4 | IRAK | TKL | 5k7i | B | | (3~{a}~{r},7~{a}~{s})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 9520 | |
| IRAK4 | IRAK | TKL | 5uis | D | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7614 | |
| IRAK4 | IRAK | TKL | 5k76 | A | B | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8715 | |
| IRAK4 | IRAK | TKL | 6ege | D | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10889 | |
| IRAK4 | IRAK | TKL | 5k72 | A | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8720 | |
| IRAK4 | IRAK | TKL | 2oib | B | B | - | Human | 1743 | |
| IRAK4 | IRAK | TKL | 6o8u | C | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11116 | |
| IRAK4 | IRAK | TKL | 6n8g | A | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10795 | |
| IRAK4 | IRAK | TKL | 4ztm | D | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 5999 | |
| IRAK4 | IRAK | TKL | 6rfi | A | B | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11787 | |
| IRAK4 | IRAK | TKL | 6ti8 | A | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12954 | |
| IRAK4 | IRAK | TKL | 6ege | A | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10891 | |
| IRAK4 | IRAK | TKL | 4ztl | C | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5990 | |
| IRAK4 | IRAK | TKL | 4yo6 | C | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1780 | |
| IRAK4 | IRAK | TKL | 5k7i | A | | (3~{a}~{r},7~{a}~{s})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 9521 | |
| IRAK4 | IRAK | TKL | 5k76 | B | A | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8709 | |
| IRAK4 | IRAK | TKL | 2oid | D | | phosphoaminophosphonic acid-adenylate ester | Human | 1733 | |
| IRAK4 | IRAK | TKL | 5w84 | B | | 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]pyridine-3-carboxamide | Human | 8561 | |
| IRAK4 | IRAK | TKL | 8tvn | A | B | n-{1-[(1r,2s)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15341 | |
| IRAK4 | IRAK | TKL | 6ega | B | A | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10912 | |
| IRAK4 | IRAK | TKL | 4yo6 | C | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1737 | |
| IRAK4 | IRAK | TKL | 4ztl | B | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6004 | |
| IRAK4 | IRAK | TKL | 6o95 | C | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11097 | |
| IRAK4 | IRAK | TKL | 5k75 | B | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8717 | |
| IRAK4 | IRAK | TKL | 5k72 | C | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8723 | |
| IRAK4 | IRAK | TKL | 6f3g | B | | ~{n}4,~{n}4-dimethyl-~{n}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | Human | 9927 | |
| IRAK4 | IRAK | TKL | 2nry | B | A | staurosporine | Human | 1758 | |
| IRAK4 | IRAK | TKL | 2nry | D | A | staurosporine | Human | 1789 | |
| IRAK4 | IRAK | TKL | 6uya | D | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11809 | |
| IRAK4 | IRAK | TKL | 5k75 | D | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8718 | |
| IRAK4 | IRAK | TKL | 8ucc | B | | (4s)-2-[(1r,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-n-[(8s)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide | Human | 15342 | |
| IRAK4 | IRAK | TKL | 4ztl | D | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6000 | |
| IRAK4 | IRAK | TKL | 5k75 | C | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8724 | |
| IRAK4 | IRAK | TKL | 6egd | A | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10895 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10911 | |
| IRAK4 | IRAK | TKL | 6tia | A | | 4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12955 | |
| IRAK4 | IRAK | TKL | 5uis | A | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7598 | |
| IRAK4 | IRAK | TKL | 5k7g | C | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8707 | |
| IRAK4 | IRAK | TKL | 6rfj | A | | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | 11786 | |
| IRAK4 | IRAK | TKL | 2nru | C | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1771 | |
| IRAK4 | IRAK | TKL | 4yo6 | D | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1788 | |
| IRAK4 | IRAK | TKL | 4yo6 | D | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1768 | |
| IRAK4 | IRAK | TKL | 7c2w | C | A | - | Human | 13002 | |
| IRAK4 | IRAK | TKL | 6ega | A | A | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10908 | |
| IRAK4 | IRAK | TKL | 6thw | B | | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12956 | |
| IRAK4 | IRAK | TKL | 4ztn | C | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6008 | |
| IRAK4 | IRAK | TKL | 6ti8 | D | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12957 | |
| IRAK4 | IRAK | TKL | 6f3e | A | | 2-[(3~{r})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide | Human | 9923 | |