| ITK | Tec | TK | 4mf0 | A | | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 77 | |
| ITK | Tec | TK | 3mj1 | A | | 7-[(4-methylpiperazin-1-yl)methyl]-4-[(3-methyl-1h-pyrazol-5-yl)amino]-2-(tetrahydro-2h-pyran-4-yl)phthalazin-1(2h)-one | Human | 27 | |
| ITK | Tec | TK | 4rfm | A | B | (4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | Human | 69 | |
| ITK | Tec | TK | 4ppc | B | A | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 78 | |
| ITK | Tec | TK | 4mf1 | B | A | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 12 | |
| ITK | Tec | TK | 3miy | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 46 | |
| ITK | Tec | TK | 3v5l | A | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 30 | |
| ITK | Tec | TK | 4kio | B | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 36 | |
| ITK | Tec | TK | 3t9t | A | B | (2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide | Human | 83 | |
| ITK | Tec | TK | 4kio | C | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 75 | |
| ITK | Tec | TK | 4mf1 | A | A | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 41 | |
| ITK | Tec | TK | 4ppc | A | A | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 53 | |
| ITK | Tec | TK | 3v8t | A | A | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 55 | |
| ITK | Tec | TK | 4kio | A | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 79 | |
| ITK | Tec | TK | 3miy | B | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 8 | |
| ITK | Tec | TK | 3qgw | A | A | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 11 | |
| ITK | Tec | TK | 4m12 | A | A | - | Human | 22 | |
| ITK | Tec | TK | 4m0y | A | B | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 70 | |
| ITK | Tec | TK | 1snu | A | | staurosporine | Human | 82 | |
| ITK | Tec | TK | 4m0z | A | B | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 47 | |
| ITK | Tec | TK | 4m12 | A | B | - | Human | 51 | |
| ITK | Tec | TK | 3mj2 | A | | n-[5-({5-[(4-acetylpiperazin-1-yl)carbonyl]-4-methoxy-2-methylphenyl}sulfanyl)-1,3-thiazol-2-yl]-4-({[(1s)-1,2,2-trimethylpropyl]amino}methyl)benzamide | Human | 67 | |
| ITK | Tec | TK | 4ppb | A | | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 29 | |
| ITK | Tec | TK | 3v5l | D | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 56 | |
| ITK | Tec | TK | 3v8t | B | B | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 49 | |
| ITK | Tec | TK | 4kio | B | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 48 | |
| ITK | Tec | TK | 4pp9 | B | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide | Human | 40 | |
| ITK | Tec | TK | 4m0z | A | A | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 45 | |
| ITK | Tec | TK | 3qgw | B | A | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 65 | |
| ITK | Tec | TK | 3qgw | A | B | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 57 | |
| ITK | Tec | TK | 4ppc | A | B | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 13 | |
| ITK | Tec | TK | 4l7s | B | B | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 25 | |
| ITK | Tec | TK | 3v8t | A | B | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 5 | |
| ITK | Tec | TK | 3v5j | A | | 3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol | Human | 80 | |
| ITK | Tec | TK | 3qgy | B | A | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 52 | |
| ITK | Tec | TK | 4pqn | A | A | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide | Human | 42 | |
| ITK | Tec | TK | 4qd6 | A | B | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 59 | |
| ITK | Tec | TK | 4mf1 | B | B | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 18 | |
| ITK | Tec | TK | 1sm2 | A | | staurosporine | Human | 74 | |
| ITK | Tec | TK | 4kio | A | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 76 | |
| ITK | Tec | TK | 4pp9 | A | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide | Human | 20 | |
| ITK | Tec | TK | 4m14 | A | | 4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1h-pyrazole-3-carboxamide | Human | 58 | |
| ITK | Tec | TK | 3qgy | B | B | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 66 | |
| ITK | Tec | TK | 4kio | C | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 7 | |
| ITK | Tec | TK | 4hcv | A | | 3-{4-amino-1-[(3s)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 32 | |
| ITK | Tec | TK | 1snx | B | | - | Human | 62 | |
| ITK | Tec | TK | 4qd6 | B | A | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 24 | |
| ITK | Tec | TK | 3qgy | A | A | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 35 | |
| ITK | Tec | TK | 4qd6 | A | A | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 23 | |
| ITK | Tec | TK | 4rfm | A | A | (4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | Human | 68 | |
| ITK | Tec | TK | 3v5j | B | | 3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol | Human | 60 | |
| ITK | Tec | TK | 4kio | D | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 85 | |
| ITK | Tec | TK | 3v8w | B | | 3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 10 | |
| ITK | Tec | TK | 4ppb | B | | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 84 | |
| ITK | Tec | TK | 3t9t | A | A | (2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide | Human | 16 | |
| ITK | Tec | TK | 4kio | D | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 6 | |
| ITK | Tec | TK | 4m13 | A | B | - | Human | 15 | |
| ITK | Tec | TK | 4l7s | A | B | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 64 | |
| ITK | Tec | TK | 4pqn | A | B | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide | Human | 19 | |
| ITK | Tec | TK | 4l7s | B | A | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 37 | |
| ITK | Tec | TK | 4mf1 | A | B | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 34 | |
| ITK | Tec | TK | 4l7s | A | A | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 50 | |
| ITK | Tec | TK | 3v5l | C | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 26 | |
| ITK | Tec | TK | 4hct | A | | 3-{1-[(3r)-1-acryloylpiperidin-3-yl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-(3-tert-butylphenyl)benzamide | Human | 44 | |
| ITK | Tec | TK | 3v5l | B | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 54 | |
| ITK | Tec | TK | 4m15 | A | | adenosine-5'-diphosphate | Human | 31 | |
| ITK | Tec | TK | 3qgy | A | B | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 72 | |
| ITK | Tec | TK | 4ppc | B | B | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 63 | |
| ITK | Tec | TK | 4m13 | A | A | - | Human | 17 | |
| ITK | Tec | TK | 4ppa | B | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 21 | |
| ITK | Tec | TK | 3v8t | B | A | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 39 | |
| ITK | Tec | TK | 3qgw | B | B | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 14 | |
| ITK | Tec | TK | 1snu | B | | staurosporine | Human | 33 | |
| ITK | Tec | TK | 3v8w | A | | 3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 43 | |
| ITK | Tec | TK | 4m0y | A | A | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 9 | |
| ITK | Tec | TK | 4mf0 | B | | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 28 | |
| ITK | Tec | TK | 4ppa | A | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 38 | |
| ITK | Tec | TK | 4qd6 | B | B | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 71 | |
| ITK | Tec | TK | 1sm2 | B | | staurosporine | Human | 73 | |
| ITK | Tec | TK | 1snx | A | | - | Human | 61 | |
| ITK | Tec | TK | 4hcu | A | | 3-{4-amino-1-[(3r)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 81 | |
