| JAK2 | JakA | TK | 8bx6 | A | A | cerdulatinib | Human | 15033 | |
| JAK2 | JakA | TK | 8bx6 | A | B | cerdulatinib | Human | 15042 | |
| JAK2 | JakA | TK | 3e64 | A | A | 4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide | Human | 3646 | |
| JAK2 | JakA | TK | 8bpv | A | B | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | Human | 15036 | |
| JAK2 | JakA | TK | 5wev | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8377 | |
| JAK2 | JakA | TK | 6vgl | B | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13222 | |
| JAK2 | JakA | TK | 6wtn | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13538 | |
| JAK2 | JakA | TK | 3lpb | A | A | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3672 | |
| JAK2 | JakA | TK | 5tq6 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7354 | |
| JAK2 | JakA | TK | 4bbf | D | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3663 | |
| Jak2 (JAK2) | JakA | TK | 4gl9 | D | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Mouse | 6935 | |
| Jak2 (JAK2) | JakA | TK | 4gl9 | B | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Mouse | 6936 | |
| Jak2 (JAK2) | JakA | TK | 4gl9 | C | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Mouse | 6934 | |
| Jak2 (JAK2) | JakA | TK | 4gl9 | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Mouse | 6933 | |
| JAK2 | JakA | TK | 7uyw | A | A | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14333 | |
| JAK2 | JakA | TK | 8bm2 | A | A | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | Human | 15043 | |
| JAK2 | JakA | TK | 7ree | A | B | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | Human | 13856 | |
| JAK2 | JakA | TK | 8bxc | A | B | itacitinib | Human | 15041 | |
| JAK2 | JakA | TK | 9t1u | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15577 | |
| JAK2 | JakA | TK | 29rx | A | B | adenosine-5'-diphosphate | Human | 15575 | |
| JAK2 | JakA | TK | 5cf4 | B | | n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5982 | |
| JAK2 | JakA | TK | 9t1u | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15576 | |
| JAK2 | JakA | TK | 9t1z | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15578 | |
| JAK2 | JakA | TK | 4f08 | B | | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3719 | |
| JAK2 | JakA | TK | 4iva | A | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3673 | |
| JAK2 | JakA | TK | 4aqc | B | B | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3676 | |
| JAK2 | JakA | TK | 3tjd | B | | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide | Human | 3626 | |
| JAK2 | JakA | TK | 4e4m | A | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3713 | |
| JAK2 | JakA | TK | 4iva | A | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3725 | |
| JAK2 | JakA | TK | 8g8x | A | A | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | Human | 14804 | |
| JAK2 | JakA | TK | 7teu | A | A | 3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14806 | |
| JAK2 | JakA | TK | 8g6z | A | A | (3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile | Human | 14808 | |
| JAK2 | JakA | TK | 8g8o | A | B | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | Human | 14809 | |
| JAK2 | JakA | TK | 8g8o | A | A | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | Human | 14807 | |
| JAK2 | JakA | TK | 3jy9 | A | B | (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one | Human | 3716 | |
| JAK2 | JakA | TK | 7teu | A | B | 3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14811 | |
| JAK2 | JakA | TK | 4c61 | A | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | Human | 3661 | |
| JAK2 | JakA | TK | 5tq3 | B | A | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7360 | |
| JAK2 | JakA | TK | 3q32 | A | | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | Human | 3700 | |
| JAK2 | JakA | TK | 8g6z | A | B | (3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile | Human | 14810 | |
| JAK2 | JakA | TK | 6aaj | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10515 | |
| JAK2 | JakA | TK | 4gfm | A | A | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3680 | |
| JAK2 | JakA | TK | 8bx9 | A | B | ilginatinib | Human | 15034 | |
| JAK2 | JakA | TK | 6vnj | A | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13340 | |
| JAK2 | JakA | TK | 29ry | A | B | - | Human | 15569 | |
| JAK2 | JakA | TK | 6tpd | A | | 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one | Human | 12350 | |
| JAK2 | JakA | TK | 3io7 | A | | (3s)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-n,n-diethylpiperidine-3-carboxamide | Human | 3636 | |
| JAK2 | JakA | TK | 8bxh | A | A | momelotinib | Human | 15032 | |
| JAK2 | JakA | TK | 4e4m | D | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3669 | |
| JAK2 | JakA | TK | 4ytc | A | B | n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine | Human | 3687 | |
| JAK2 | JakA | TK | 9t20 | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15570 | |
| JAK2 | JakA | TK | 6vnh | B | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13342 | |
| JAK2 | JakA | TK | 4aqc | A | B | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3696 | |
| JAK2 | JakA | TK | 6vgl | D | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13220 | |
| JAK2 | JakA | TK | 6x8e | A | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13152 | |
| JAK2 | JakA | TK | 5usy | B | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8104 | |
| JAK2 | JakA | TK | 6vn8 | A | | baricitinib | Human | 13291 | |
| JAK2 | JakA | TK | 9t20 | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15572 | |
| JAK2 | JakA | TK | 5tq7 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7355 | |
| JAK2 | JakA | TK | 6wto | A | A | baricitinib | Human | 13536 | |
| JAK2 | JakA | TK | 5tq6 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7361 | |
| JAK2 | JakA | TK | 3jy9 | A | A | (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one | Human | 3668 | |
| JAK2 | JakA | TK | 6bbv | A | | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9504 | |
| JAK2 | JakA | TK | 4bbe | A | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3670 | |
| JAK2 | JakA | TK | 5cf4 | A | | n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5980 | |
| JAK2 | JakA | TK | 4c62 | A | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | Human | 3655 | |
| JAK2 | JakA | TK | 9t1z | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15573 | |
| JAK2 | JakA | TK | 6vs3 | B | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13345 | |
| JAK2 | JakA | TK | 5cf5 | B | | n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5976 | |
| JAK2 | JakA | TK | 3fup | B | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3654 | |
| JAK2 | JakA | TK | 4d1s | A | B | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3627 | |
| JAK2 | JakA | TK | 4c61 | B | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | Human | 3645 | |
| JAK2 | JakA | TK | 6wtq | A | B | n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | Human | 13537 | |
| JAK2 | JakA | TK | 3zmm | B | A | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3709 | |
| JAK2 | JakA | TK | 4e6d | B | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3631 | |
| JAK2 | JakA | TK | 8bxc | A | A | itacitinib | Human | 15037 | |
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13346 | |
| JAK2 | JakA | TK | 6vnk | A | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13293 | |
| JAK2 | JakA | TK | 4yti | A | A | (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide | Human | 3641 | |
| JAK2 | JakA | TK | 4e6q | A | | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3624 | |
| JAK2 | JakA | TK | 4p7e | B | | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3701 | |
| JAK2 | JakA | TK | 3kck | A | B | 3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | Human | 3722 | |
| JAK2 | JakA | TK | 5l3a | A | A | ~{n}-(1~{h}-indazol-4-yl)methanesulfonamide | Human | 6561 | |
| JAK2 | JakA | TK | 8bx9 | A | A | ilginatinib | Human | 15038 | |
| JAK2 | JakA | TK | 4yth | A | B | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide | Human | 3702 | |
| JAK2 | JakA | TK | 4ytf | A | A | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide | Human | 3690 | |
| JAK2 | JakA | TK | 5hez | C | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7253 | |
| JAK2 | JakA | TK | 3e63 | A | A | 5-phenyl-1h-indazol-3-amine | Human | 3675 | |
| JAK2 | JakA | TK | 8g8x | A | B | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | Human | 14805 | |
| JAK2 | JakA | TK | 5tq3 | A | A | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7359 | |
| JAK2 | JakA | TK | 4gmy | A | | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3684 | |
| JAK2 | JakA | TK | 6x8e | B | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13153 | |
| JAK2 | JakA | TK | 6vnk | B | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13295 | |
| JAK2 | JakA | TK | 6x8e | A | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13154 | |
| JAK2 | JakA | TK | 3q32 | B | | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | Human | 3639 | |
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13347 | |
| JAK2 | JakA | TK | 6wto | A | B | baricitinib | Human | 13539 | |
| JAK2 | JakA | TK | 5tq4 | A | | 6-(2-ethyl-4-hydroxyphenyl)-1h-indazole-3-carboxamide | Human | 7351 | |
| JAK2 | JakA | TK | 5hez | D | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7252 | |
| JAK2 | JakA | TK | 7q7w | A | A | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14087 | |
| JAK2 | JakA | TK | 4bbe | B | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3727 | |
| JAK2 | JakA | TK | 6vnc | B | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13348 | |
| JAK2 | JakA | TK | 7q7i | A | B | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | Human | 14088 | |
| JAK2 | JakA | TK | 6vne | A | | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | 13296 | |
| JAK2 | JakA | TK | 5cf6 | B | | n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5977 | |
| JAK2 | JakA | TK | 6vs3 | A | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13349 | |
| JAK2 | JakA | TK | 5cf8 | A | B | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5981 | |
| JAK2 | JakA | TK | 4f09 | A | | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3622 | |
| JAK2 | JakA | TK | 6vnm | B | | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 13351 | |
| JAK2 | JakA | TK | 6wtn | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13540 | |
| JAK2 | JakA | TK | 5tq8 | A | | {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2h-indazol-3-yl]-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone | Human | 7357 | |
| JAK2 | JakA | TK | 6vnl | D | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13297 | |
| JAK2 | JakA | TK | 6drw | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10512 | |
| JAK2 | JakA | TK | 4c62 | B | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | Human | 3625 | |
| JAK2 | JakA | TK | 4aqc | A | A | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3720 | |
| JAK2 | JakA | TK | 5tq5 | A | | 6-(2-ethyl-4-hydroxyphenyl)-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide | Human | 7358 | |
| JAK2 | JakA | TK | 6vsn | A | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13353 | |
| JAK2 | JakA | TK | 4jia | A | B | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3640 | |
| JAK2 | JakA | TK | 29ry | A | A | - | Human | 15574 | |
| JAK2 | JakA | TK | 3ugc | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3651 | |
| JAK2 | JakA | TK | 2b7a | B | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3728 | |
| JAK2 | JakA | TK | 7q7w | A | B | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14089 | |
| JAK2 | JakA | TK | 3lpb | A | B | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3698 | |
| JAK2 | JakA | TK | 5usy | B | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8103 | |
| JAK2 | JakA | TK | 4zim | A | B | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3659 | |
| JAK2 | JakA | TK | 6drw | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10513 | |
| JAK2 | JakA | TK | 6vn8 | B | | baricitinib | Human | 13301 | |
| JAK2 | JakA | TK | 3ugc | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3632 | |
| JAK2 | JakA | TK | 4zim | A | A | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3704 | |
| JAK2 | JakA | TK | 6vsn | B | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13356 | |
| JAK2 | JakA | TK | 3tjc | B | | 4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | Human | 3688 | |
| JAK2 | JakA | TK | 3lpb | B | A | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3635 | |
| JAK2 | JakA | TK | 4jia | A | A | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3691 | |
| JAK2 | JakA | TK | 4zim | B | B | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3697 | |
| JAK2 | JakA | TK | 3e62 | A | A | 5-bromo-1h-indazol-3-amine | Human | 3665 | |
| JAK2 | JakA | TK | 5usy | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8101 | |
| JAK2 | JakA | TK | 5l3a | A | B | ~{n}-(1~{h}-indazol-4-yl)methanesulfonamide | Human | 6560 | |
| JAK2 | JakA | TK | 4yth | A | A | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide | Human | 3710 | |
| JAK2 | JakA | TK | 4hge | A | B | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3658 | |
| JAK2 | JakA | TK | 4aqc | B | A | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3679 | |
| JAK2 | JakA | TK | 5tq7 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7353 | |
| JAK2 | JakA | TK | 7q7i | A | A | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | Human | 14085 | |
| JAK2 | JakA | TK | 3krr | A | A | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 3643 | |
| JAK2 | JakA | TK | 4hge | B | A | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3706 | |
| JAK2 | JakA | TK | 7q7k | A | A | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | Human | 14091 | |
| JAK2 | JakA | TK | 6vnb | A | | (3s)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13298 | |
| JAK2 | JakA | TK | 6vsn | D | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13343 | |
| JAK2 | JakA | TK | 6vng | B | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13341 | |
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13352 | |
| JAK2 | JakA | TK | 5aep | A | B | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide | Human | 3686 | |
| JAK2 | JakA | TK | 3krr | A | B | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 3695 | |
| JAK2 | JakA | TK | 4f08 | A | | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3662 | |
| JAK2 | JakA | TK | 6wtq | A | A | n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | Human | 13535 | |
| JAK2 | JakA | TK | 4bbe | D | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3726 | |
| JAK2 | JakA | TK | 3kck | A | A | 3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | Human | 3683 | |
| JAK2 | JakA | TK | 29rx | A | A | adenosine-5'-diphosphate | Human | 15571 | |
| JAK2 | JakA | TK | 5cf8 | B | B | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5983 | |
| JAK2 | JakA | TK | 4bbe | C | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3649 | |
| JAK2 | JakA | TK | 7ll4 | A | A | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14035 | |
| JAK2 | JakA | TK | 4ytf | A | B | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide | Human | 3693 | |
| JAK2 | JakA | TK | 7ree | A | A | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | Human | 13855 | |
| JAK2 | JakA | TK | 6vgl | C | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13221 | |
| JAK2 | JakA | TK | 4e6d | B | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3647 | |
| JAK2 | JakA | TK | 5tq3 | A | B | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7356 | |
| JAK2 | JakA | TK | 2xa4 | B | B | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3707 | |
| JAK2 | JakA | TK | 4bbf | C | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3644 | |
| JAK2 | JakA | TK | 8bm2 | A | B | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | Human | 15035 | |
| JAK2 | JakA | TK | 4e6d | A | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3689 | |
| JAK2 | JakA | TK | 6vnh | A | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13344 | |
| JAK2 | JakA | TK | 5cf8 | A | A | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5978 | |
| JAK2 | JakA | TK | 4p7e | A | | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3682 | |
| JAK2 | JakA | TK | 3lpb | B | B | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3681 | |
| JAK2 | JakA | TK | 3zmm | A | A | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3674 | |
| JAK2 | JakA | TK | 6vnk | D | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13292 | |
| JAK2 | JakA | TK | 4ji9 | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3724 | |
| JAK2 | JakA | TK | 4zim | B | A | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3660 | |
| JAK2 | JakA | TK | 3e64 | A | B | 4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide | Human | 3653 | |
| JAK2 | JakA | TK | 8bpw | A | B | lestaurtinib | Human | 15039 | |
| JAK2 | JakA | TK | 4e6q | B | | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3671 | |
| JAK2 | JakA | TK | 5tq3 | B | B | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7352 | |
| JAK2 | JakA | TK | 6vni | A | | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | Human | 13294 | |
| JAK2 | JakA | TK | 7uyw | A | B | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14334 | |
| JAK2 | JakA | TK | 4e6d | A | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3656 | |
| JAK2 | JakA | TK | 3tjc | A | | 4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | Human | 3685 | |
| JAK2 | JakA | TK | 2w1i | A | | 4-[(2-{4-[(cyclopropylcarbamoyl)amino]-1h-pyrazol-3-yl}-1h-benzimidazol-6-yl)methyl]morpholin-4-ium | Human | 3652 | |
| JAK2 | JakA | TK | 3tjd | A | | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide | Human | 3677 | |
| JAK2 | JakA | TK | 3e63 | A | B | 5-phenyl-1h-indazol-3-amine | Human | 3711 | |
| JAK2 | JakA | TK | 4yti | A | B | (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide | Human | 3657 | |
| JAK2 | JakA | TK | 6vgl | A | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13223 | |
| JAK2 | JakA | TK | 3iok | A | A | 3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | Human | 3694 | |
| JAK2 | JakA | TK | 7q7k | A | B | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | Human | 14086 | |
| JAK2 | JakA | TK | 8bpv | A | A | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | Human | 15040 | |
| JAK2 | JakA | TK | 4e4m | B | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3712 | |
| JAK2 | JakA | TK | 7rn6 | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13955 | |
| JAK2 | JakA | TK | 6vsn | C | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13350 | |
| JAK2 | JakA | TK | 6wtp | A | A | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | 13541 | |
| JAK2 | JakA | TK | 6vnl | B | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13299 | |
| JAK2 | JakA | TK | 7q7l | A | B | 4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14090 | |
| JAK2 | JakA | TK | 4gfm | A | B | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3705 | |
| JAK2 | JakA | TK | 4e4m | E | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3637 | |
| JAK2 | JakA | TK | 4d1s | A | A | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3634 | |
| JAK2 | JakA | TK | 4d0x | A | A | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | Human | 3699 | |
| JAK2 | JakA | TK | 5cf8 | B | A | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5985 | |
| JAK2 | JakA | TK | 6vnm | A | | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 13354 | |
| JAK2 | JakA | TK | 5hez | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7255 | |
| JAK2 | JakA | TK | 6vnl | C | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13300 | |
| JAK2 | JakA | TK | 5wev | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8376 | |
| JAK2 | JakA | TK | 4hge | A | A | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3703 | |
| JAK2 | JakA | TK | 4bbf | B | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3717 | |
| JAK2 | JakA | TK | 3zmm | B | B | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3678 | |
| JAK2 | JakA | TK | 7rn6 | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13956 | |
| JAK2 | JakA | TK | 2xa4 | B | A | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3628 | |
| JAK2 | JakA | TK | 3fup | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3721 | |
| JAK2 | JakA | TK | 4bbf | A | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3723 | |
| JAK2 | JakA | TK | 5aep | A | A | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide | Human | 3629 | |
| JAK2 | JakA | TK | 2xa4 | A | B | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3623 | |
| JAK2 | JakA | TK | 2xa4 | A | A | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3664 | |
| JAK2 | JakA | TK | 2b7a | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3708 | |
| JAK2 | JakA | TK | 3zmm | A | B | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3667 | |
| JAK2 | JakA | TK | 3e62 | A | B | 5-bromo-1h-indazol-3-amine | Human | 3630 | |
| JAK2 | JakA | TK | 3iok | A | B | 3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | Human | 3718 | |
| JAK2 | JakA | TK | 5hez | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7254 | |
| JAK2 | JakA | TK | 6x8e | B | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13155 | |
| JAK2 | JakA | TK | 6vne | B | | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | 13302 | |
| JAK2 | JakA | TK | 3rvg | A | | 1-(cyclohexylamino)-7-(1-methyl-1h-pyrazol-4-yl)-5h-pyrido[4,3-b]indole-4-carboxamide | Human | 3638 | |
| JAK2 | JakA | TK | 4d0w | A | B | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide | Human | 3650 | |
| JAK2 | JakA | TK | 7ll5 | A | A | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14036 | |
| JAK2 | JakA | TK | 6aaj | B | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10514 | |
| JAK2 | JakA | TK | 8bpw | A | A | lestaurtinib | Human | 15044 | |
| JAK2 | JakA | TK | 6vnl | A | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13303 | |
| JAK2 | JakA | TK | 6vnk | C | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13304 | |
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13357 | |
| JAK2 | JakA | TK | 5cf5 | A | | n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5984 | |
| JAK2 | JakA | TK | 5cf6 | A | | n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5979 | |
| JAK2 | JakA | TK | 4hge | B | B | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3715 | |
| JAK2 | JakA | TK | 7q7l | A | A | 4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14092 | |
| JAK2 | JakA | TK | 7ll4 | A | B | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14037 | |
| JAK2 | JakA | TK | 6vng | A | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13358 | |
| JAK2 | JakA | TK | 7ll5 | A | B | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14038 | |
| JAK2 | JakA | TK | 2w1i | B | | - | Human | 3648 | |
| JAK2 | JakA | TK | 8bxh | A | B | momelotinib | Human | 15045 | |
| JAK2 | JakA | TK | 4ji9 | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3692 | |
| JAK2 | JakA | TK | 6vnc | A | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13359 | |
| JAK2 | JakA | TK | 4ytc | A | A | n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine | Human | 3633 | |
| JAK2 | JakA | TK | 4d0x | A | B | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | Human | 3642 | |
| JAK2 | JakA | TK | 4d0w | A | A | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide | Human | 3666 | |
| JAK2 | JakA | TK | 6wtp | A | B | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | 13542 | |
| JAK2 | JakA | TK | 6vnj | B | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13355 | |
| JAK2 | JakA | TK | 4iva | A | C | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3714 | |
| JAK2 | JakA | TK | 5usy | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8102 | |
