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Search results (234 entries covering 102 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
BRAFRAFTKL9bfbAAn-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamideHuman15365
BRAFRAFTKL9bfbABn-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamideHuman15366
BRAFRAFTKL7shvAB2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman14481
BRAFRAFTKL7shvAA2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman14482
BRAFRAFTKL5vamBAn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman8186
BRAFRAFTKL6pp9AAphosphoaminophosphonic acid-adenylate esterHuman11711
BRAFRAFTKL3psdA6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl]indeno[1,2-c]pyrazoleHuman3142
BRAFRAFTKL5jt2D-Human7066
BRAFRAFTKL6v2wAAphosphoaminophosphonic acid-adenylate esterHuman13026
BRAFRAFTKL7m0tAphosphoaminophosphonic acid-adenylate esterHuman13525
BRAFRAFTKL5cswAdabrafenibHuman6433
BRAFRAFTKL5fd2B6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{h}-purineHuman6602
BRAFRAFTKL4mneGA-Human3071
BRAFRAFTKL6b8uA~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamideHuman8679
BRAFRAFTKL6p3dA3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamideHuman12809
BRAFRAFTKL5jsmAB-Human7058
BRAFRAFTKL6uanB-Human11641
BRAFRAFTKL4mnfAB2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman3141
BRAFRAFTKL8c7yAB~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamideHuman14628
BRAFRAFTKL8c7yAA~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamideHuman14629
BRAFRAFTKL8f7pABn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman14702
BRAFRAFTKL8f7oAB6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamideHuman14703
BRAFRAFTKL8f7pAAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman14705
BRAFRAFTKL8c7xAB~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamideHuman14627
BRAFRAFTKL8f7oAA6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamideHuman14704
BRAFRAFTKL8c7xAA~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamideHuman14630
BRAFRAFTKL4mneFA-Human3099
BRAFRAFTKL4xv1B-Human6216
BRAFRAFTKL4pp7Bn-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamideHuman3126
BRAFRAFTKL3skcA2,6-difluoro-n-[(5s)-3-methoxy-5h-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamideHuman3100
BRAFRAFTKL5jsmCBn,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)Human7063
BRAFRAFTKL6cadB1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amineHuman9575
BRAFRAFTKL4g9cA3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)benzamideHuman3084
BRAFRAFTKL6u2hDA2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman11569
BRAFRAFTKL3tv4An-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamideHuman3054
BRAFRAFTKL5jsmDB-Human7053
BRAFRAFTKL7m0yAphosphoaminophosphonic acid-adenylate esterHuman13520
BRAFRAFTKL6nsqB5-[(4-amino-1-ethyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-n-(4-chlorophenyl)-6-methylisoquinolin-1-amineHuman11329
BRAFRAFTKL4fk3An-{2,4-difluoro-3-[(5-pyridin-3-yl-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamideHuman3118
BRAFRAFTKL5csxAn-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6432
BRAFRAFTKL5c9cBB1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}ureaHuman3119
BRAFRAFTKL6p7gC3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamideHuman12807
BRAFRAFTKL8dgtABphosphothiophosphoric acid-adenylate esterHuman14830
BRAFRAFTKL6p7gB3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamideHuman12806
BRAFRAFTKL4rzvAn-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6944
BRAFRAFTKL4mnfBA2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman3124
BRAFRAFTKL5c9cBA1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}ureaHuman3138
BRAFRAFTKL4mneGB-Human3073
BRAFRAFTKL4xv2AdabrafenibHuman6213
BRAFRAFTKL6q0jBB-Human11712
BRAFRAFTKL5jsmDA-Human7055
BRAFRAFTKL4rzwB3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman6942
BRAFRAFTKL4wo5Bn-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamideHuman3143
BRAFRAFTKL5vamBBn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman8187
BRAFRAFTKL3prfB2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenolHuman3139
BRAFRAFTKL7p3vA~{n}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{s})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamideHuman13961
BRAFRAFTKL6q0jBA-Human11703
BRAFRAFTKL3tv6A2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamideHuman3080
BRAFRAFTKL5jsmAA-Human7056
BRAFRAFTKL7m0zAphosphoaminophosphonic acid-adenylate esterHuman13521
BRAFRAFTKL5jsmCAn,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)Human7059
BRAFRAFTKL4xv1An'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-n-ethyl-n-methylsulfuric diamideHuman6214
BRAFRAFTKL6uuoB1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-5-yl](methyl)amino}pyridin-1(4h)-yl]ethan-1-oneHuman12346
BRAFRAFTKL5ct7B1-methyl-5-({2-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-4-yl}oxy)-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amineHuman6033
BRAFRAFTKL5hieDAdabrafenibHuman6510
BRAFRAFTKL6u2hCA2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman11568
BRAFRAFTKL6q0jAA-Human11704
BRAFRAFTKL3ii5An-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamideHuman3116
BRAFRAFTKL5hidBB3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman6517
BRAFRAFTKL3psbBethyl 3-{[1-(hydroxyamino)-2h-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylateHuman3125
BRAFRAFTKL4r5yB5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-oneHuman6413
BRAFRAFTKL6n0qBAn-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamideHuman11770
BRAFRAFTKL6q0tBB-Human11700
BRAFRAFTKL4pp7An-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamideHuman3094
BRAFRAFTKL5jt2B-Human7057
BRAFRAFTKL4fc0B2-chloro-3-[(2-cyanopropan-2-yl)oxy]-n-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamideHuman3069
BRAFRAFTKL5hieAAdabrafenibHuman6516
BRAFRAFTKL4mneBA-Human3075
BRAFRAFTKL2fb8A(1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oximeHuman3062
BRAFRAFTKL5jrqB(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]methanoneHuman7054
BRAFRAFTKL3tv4Bn-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamideHuman3133
BRAFRAFTKL1uwjB4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman3105
BRAFRAFTKL4xv3An'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-n-ethyl-n-methylsulfuric diamideHuman6217
BRAFRAFTKL5hidAA3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman6506
BRAFRAFTKL3ii5Bn-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamideHuman3076
BRAFRAFTKL5hieCBdabrafenibHuman6507
BRAFRAFTKL4xv3B-Human6218
BRAFRAFTKL5fd2A6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{h}-purineHuman6603
BRAFRAFTKL4rzwA3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman6939
BRAFRAFTKL2fb8B(1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oximeHuman3086
BRAFRAFTKL5hieBBdabrafenibHuman6505
BRAFRAFTKL4ksqBn-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamideHuman3055
BRAFRAFTKL6u2gBphosphomethylphosphonic acid adenylate esterHuman11567
BRAFRAFTKL3ppjBmethyl 3-{[(5s)-1-(hydroxyamino)-5h-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylateHuman3087
BRAFRAFTKL4dbnA2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamideHuman3052
BRAFRAFTKL4cqeBn-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamideHuman3107
BRAFRAFTKL5cswBdabrafenibHuman6431
BRAFRAFTKL6v2wABphosphoaminophosphonic acid-adenylate esterHuman13032
BRAFRAFTKL6n0pAAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman11597
BRAFRAFTKL3q96A(2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamideHuman3072
BRAFRAFTKL3og7B-Human3140
BRAFRAFTKL4e4xBn-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamideHuman3104
BRAFRAFTKL6v34A6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamideHuman13200
BRAFRAFTKL6cadA1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amineHuman9576
BRAFRAFTKL3idpAn~1~-(4-chlorophenyl)-6-methyl-n~5~-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamineHuman3077
BRAFRAFTKL4rzvBn-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6941
BRAFRAFTKL4jvgA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman3134
BRAFRAFTKL4jvgB1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman3085
BRAFRAFTKL4h58ABn-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amineHuman3110
BRAFRAFTKL5hieCAdabrafenibHuman6513
BRAFRAFTKL3idpBn~1~-(4-chlorophenyl)-6-methyl-n~5~-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamineHuman3121
BRAFRAFTKL1uwhA4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman3127
BRAFRAFTKL4xv9AAn-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamideHuman6220
BRAFRAFTKL4r5yA5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-oneHuman6414
BRAFRAFTKL6p7gA3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamideHuman12810
BRAFRAFTKL3d4qA(1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oximeHuman3095
BRAFRAFTKL6n0pABn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman11596
BRAFRAFTKL5hidAB3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman6512
BRAFRAFTKL4xv9ABn-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamideHuman6215
BRAFRAFTKL6xagCA-Human12922
BRAFRAFTKL4e4xAn-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamideHuman3051
BRAFRAFTKL3skcB2,6-difluoro-n-[(5s)-3-methoxy-5h-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamideHuman3128
BRAFRAFTKL6q0tAB-Human11707
BRAFRAFTKL4mneCA-Human3122
BRAFRAFTKL6q0tAA-Human11705
BRAFRAFTKL3q4cB-Human7250
BRAFRAFTKL3psbAethyl 3-{[1-(hydroxyamino)-2h-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylateHuman3111
BRAFRAFTKL6nybAphosphothiophosphoric acid-adenylate esterHuman11708
BRAFRAFTKL6n0qABn-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamideHuman11768
BRAFRAFTKL4kspAn-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamideHuman3081
BRAFRAFTKL4h58CA-Human3056
BRAFRAFTKL4mnfBB2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman3098
BRAFRAFTKL4h58BA-Human3097
BRAFRAFTKL4ehgAn-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamideHuman3064
BRAFRAFTKL5jsmBBn,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)Human7062
BRAFRAFTKL5hieDBdabrafenibHuman6514
BRAFRAFTKL4h58BB-Human3120
BRAFRAFTKL6pp9ABphosphoaminophosphonic acid-adenylate esterHuman11709
BRAFRAFTKL6xfpAA4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamideHuman13403
BRAFRAFTKL7k0vAAn-(3,3-dimethylbutyl)-n'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}ureaHuman13617
BRAFRAFTKL6nsqA5-[(4-amino-1-ethyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-n-(4-chlorophenyl)-6-methylisoquinolin-1-amineHuman11328
BRAFRAFTKL6v2uBdabrafenibHuman13031
BRAFRAFTKL5vamABn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman8189
BRAFRAFTKL3d4qB(1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oximeHuman3060
BRAFRAFTKL4jvgD1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman3059
BRAFRAFTKL4fc0A2-chloro-3-[(2-cyanopropan-2-yl)oxy]-n-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamideHuman3131
BRAFRAFTKL5hieBAdabrafenibHuman6509
BRAFRAFTKL7m0vAAphosphoaminophosphonic acid-adenylate esterHuman13526
BRAFRAFTKL6n0qAAn-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamideHuman11771
BRAFRAFTKL3tv6B2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamideHuman3136
BRAFRAFTKL6v2uAdabrafenibHuman13034
BRAFRAFTKL4yhtB3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6443
BRAFRAFTKL6n0pBBn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman11595
BRAFRAFTKL5jt2A2,2'-oxybis[n-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide]Human7065
BRAFRAFTKL3og7An-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman3113
BRAFRAFTKL7m0wAphosphoaminophosphonic acid-adenylate esterHuman13528
BRAFRAFTKL4yhtA3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6442
BRAFRAFTKL8dgsABphosphothiophosphoric acid-adenylate esterHuman14829
BRAFRAFTKL8dgtAAphosphothiophosphoric acid-adenylate esterHuman14832
BRAFRAFTKL8dgsAAphosphothiophosphoric acid-adenylate esterHuman14831
BRAFRAFTKL6p7gD3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamideHuman12808
BRAFRAFTKL6n0qBBn-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamideHuman11769
BRAFRAFTKL7k0vABn-(3,3-dimethylbutyl)-n'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}ureaHuman13616
BRAFRAFTKL5c9cAA1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}ureaHuman3123
BRAFRAFTKL8qqgAA(3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamideHuman15178
BRAFRAFTKL8qqgAB(3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamideHuman15179
BRAFRAFTKL5itaBn-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamideHuman6943
BRAFRAFTKL5itaAn-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamideHuman6940
BRAFRAFTKL4mneCB-Human3058
BRAFRAFTKL4h58AAn-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amineHuman3137
BRAFRAFTKL4mneBB-Human3061
BRAFRAFTKL6q0kB-Human11710
BRAFRAFTKL4jvgC1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman3050
BRAFRAFTKL3priA3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1h-indazol-3-yl)propan-1-olHuman3093
BRAFRAFTKL3ppkA3-[(5-hydroxynaphthalen-2-yl)amino]-n-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamideHuman3106
BRAFRAFTKL7mfdA-Human14077
BRAFRAFTKL6q0tBA-Human11702
BRAFRAFTKL5ct7A1-methyl-5-({2-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-4-yl}oxy)-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amineHuman6032
BRAFRAFTKL4fk3B-Human3068
BRAFRAFTKL4h58CB-Human3114
BRAFRAFTKL5jsmBAn,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)Human7060
BRAFRAFTKL6uanC-Human11642
BRAFRAFTKL7mfeA-Human14078
BRAFRAFTKL4wo5An-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamideHuman3079
BRAFRAFTKL6v34B6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamideHuman13199
BRAFRAFTKL6xloA3-(2-cyanopropan-2-yl)-n-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamideHuman13618
BRAFRAFTKL4g9cB3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)benzamideHuman3067
BRAFRAFTKL3psdB6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl]indeno[1,2-c]pyrazoleHuman3083
BRAFRAFTKL3q4cA[(1,2,3,4,5,6-eta)-(1s,2r,3r,4r,5s,6s)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5h-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~n~1~,n~12~)ruthenium(1+)Human7251
BRAFRAFTKL6xfpAB4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamideHuman13404
BRAFRAFTKL5valBn-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamideHuman8188
BRAFRAFTKL5jrqA(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]methanoneHuman7061
BRAFRAFTKL7m0vABphosphoaminophosphonic acid-adenylate esterHuman13522
BRAFRAFTKL3c4cAn-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamideHuman3115
BRAFRAFTKL4e26B5-chloro-7-[(r)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-olHuman3102
BRAFRAFTKL5vamAAn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman8185
BRAFRAFTKL4ksqAn-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamideHuman3065
BRAFRAFTKL1uwhB4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman3109
BRAFRAFTKL3priB3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1h-indazol-3-yl)propan-1-olHuman3103
BRAFRAFTKL4g9rA3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman3130
BRAFRAFTKL7m0xABphosphoaminophosphonic acid-adenylate esterHuman13523
BRAFRAFTKL4dbnB2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamideHuman3070
BRAFRAFTKL4cqeAn-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamideHuman3088
BRAFRAFTKL6xagDA-Human12921
BRAFRAFTKL5valAn-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamideHuman8190
BRAFRAFTKL7m0xAAphosphoaminophosphonic acid-adenylate esterHuman13524
BRAFRAFTKL6n0pBAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman11594
BRAFRAFTKL4e26A5-chloro-7-[(r)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-olHuman3108
BRAFRAFTKL6uuoA1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-5-yl](methyl)amino}pyridin-1(4h)-yl]ethan-1-oneHuman12347
BRAFRAFTKL4xv2BdabrafenibHuman6219
BRAFRAFTKL1uwjA4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman3135
BRAFRAFTKL5hidBA3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman6511
BRAFRAFTKL4mneFB-Human3117
BRAFRAFTKL6q0jAB-Human11701
BRAFRAFTKL4eheA4-amino-n-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamideHuman3112
BRAFRAFTKL6b8uB~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamideHuman8678
BRAFRAFTKL3prfA2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenolHuman3129
BRAFRAFTKL3ppjAmethyl 3-{[(5s)-1-(hydroxyamino)-5h-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylateHuman3091
BRAFRAFTKL5hieABdabrafenibHuman6508
BRAFRAFTKL3q96B(2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamideHuman3089
BRAFRAFTKL7m0uAphosphoaminophosphonic acid-adenylate esterHuman13527
BRAFRAFTKL5jt2C2,2'-oxybis[n-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide]Human7064
BRAFRAFTKL5c9cAB1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}ureaHuman3074
BRAFRAFTKL4mbjB2,6-difluoro-n-(1h-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamideHuman3057
BRAFRAFTKL3c4cBn-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamideHuman3063
BRAFRAFTKL5hi2A4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman6515
BRAFRAFTKL4eheB4-amino-n-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamideHuman3082
BRAFRAFTKL6q0kA-Human11706
BRAFRAFTKL3ppkB3-[(5-hydroxynaphthalen-2-yl)amino]-n-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamideHuman3092
BRAFRAFTKL4g9rB3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamideHuman3101
BRAFRAFTKL4ehgBn-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamideHuman3078
BRAFRAFTKL4mbjA2,6-difluoro-n-(1h-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamideHuman3090
BRAFRAFTKL4mnfAA2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanolHuman3096
BRAFRAFTKL4kspBn-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamideHuman3066
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