KLIFS, intially developed at the Vrije Universiteit Amsterdam, is a database that dissects experimental structures of catalytic kinase domains and the way kinase inhibitors interact with them. The KLIFS structural alignment enables the comparison of all structures and ligands to each other. Moreover, the KLIFS residue numbering scheme capturing the catalytic cleft of 85 residues allows for the comparison of the interaction patterns of kinase-inhibitors to each other to, for example, identify crucial interactions determining kinase-inhibitor selectivity.

For more information you can follow the tutorial, go through the frequently asked questions (FAQ), or read our articles in Trends in Pharmacological Sciences (2019), Nucleic Acids Research (2016), and ACS Journal of Medicinal Chemistry (2014).

Statistics
Kinases308
Structures (# PDBs)5273
Monomers11427
Unique ligands3341
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News:

Release version 3.0 - the overhaul release

09-Sep-2020

Trends in Pharmacological Sciences publication (open access)

31-Oct-2019

Secure browsing with KLIFS

04-Sep-2019
News archive
Latest structures:
PDBKinaseGroupLigand
6kyqDCLK1CAMK-
6kyrDCLK1CAMK-
6p3dBRAFTKL3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
6p7gBRAFTKL3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide
6ykyMAPK6CMGC3-(4-methoxyphenyl)-~{N}-[(3~{R})-1-pyridin-4-ylpyrrolidin-3-yl]-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
6ylcMAPK6CMGC5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile
6yllMAPK6CMGC~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine
6yllMAPK6CMGC-