KLIFS is a kinase database that dissects experimental structures of catalytic kinase domains and the way kinase inhibitors interact with them. The KLIFS structural alignment enables the comparison of all structures and ligands to each other. Moreover, the KLIFS residue numbering scheme capturing the catalytic cleft with 85 residues enables the comparison of the interaction patterns of kinase-inhibitors, for example, to identify crucial interactions determining kinase-inhibitor selectivity.

For more information, go through the frequently asked questions (FAQ) or read our articles in Nucleic Acids Research (2020), Trends in Pharmacological Sciences (2019), and ACS Journal of Medicinal Chemistry (2014).

Statistics
Kinases317
Structures (# PDBs)6217
Monomers13181
Unique ligands3893
KLIFS users in Jan-20231655
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News:

2023 - a sneak peek

05-Jan-2023

KLIFS workshop @ May 19th

02-Apr-2022

Alternative coloring scheme

01-Feb-2022
News archive
Latest structures:
PDBKinaseGroupLigand
7z6uPIM1CAMK4-[(~{E})-(6-azanyl-2-oxidanylidene-1~{H}-indol-3-ylidene)methyl]benzoic acid
7zpcCDK2CMGC~{N}-(1-methylpyrazol-4-yl)-5-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxamide
8afrPIM1CAMK4-((6-hydroxybenzofuran-3-yl)methyl)benzoic acid
8c7zACVR1TKL9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1]benzoxepino[5,4-c]pyridine